MIT researchers develop GastroShield, a protective gel to prevent complications after colonoscopies
Millions undergo colonoscopies each year, a procedure that has significantly reduced colon cancer rates. However, removing large polyps can lead to complications like bleeding.
MIT engineers have created a new solution: GastroShield, a sprayable gel applied through endoscopes. This gel forms a tough yet flexible shield on the surgical site, preventing delayed bleeding and aiding tissue healing.
Endoscopic woes addressed
Current methods, like cauterization, create scars that hinder healing. Additionally, delayed bleeding or leaks can occur, requiring hospitalization. Metal clips used for reinforcement have limitations. Gels haven’t been successful due to short adherence times.
The science behind GastroShield
The MIT team created a unique material with the right properties. It needed to be:
- Low viscosity for easy spraying
- Quickly form a strong gel upon contact
- Flexible to withstand digestive tract movements
Their solution? A combination of:
- Pluronic: A self-assembling polymer forming micelles
- Oxidized dextran: A polysaccharide that bonds with the micelles
These materials react instantly, forming a solid gel in seconds. The micelles act like a self-healing network, absorbing forces and reforming. The gel even withstands the harsh digestive environment.
Promising results
Animal studies showed rapid sealing, no leaks or bleeding, and the gel lasted for five days before being naturally shed. Biocompatibility tests confirmed safety.
Beyond colonoscopies
A company, BioDevek, is developing GastroShield for human use. This technology has the potential to:
- Improve colonoscopy safety
- Treat stomach ulcers
- Help with inflammatory bowel diseases like Crohn’s disease
- Deliver targeted cancer medications
This innovative gel holds promise for a future of safer and more effective endoscopic procedures.
News Source: MIT
